Benzoyl chloride → 2-Chloroethylbenzoate

20.0 g (142 mM) of benzoyl chloride and then additionally 14.4 g (142 mM) of triethylamine were added dropwise with vigorous stirring at room temperature to a solution of 11.5 g (142 mM) of chloroethanol in 200 ml of THF (exothermic reaction). After stirring for 1 h, the mixture was concentrated on a rotary evaporator, and the residue was partitioned between methylene chloride and water and acidified with 10% strength hydrochloric acid. The aqueous phase was reextracted twice with methylene chloride and the organic phase was then concentrated after drying with sodium sulfate. 26.0 g (99%) of 2-chloroethyl benzoate were isolated.

1. concentrationthe mixture was concentrated on a rotary evaporator
2. customthe residue was partitioned between methylene chloride and water
3. concentrationthe organic phase was then concentrated
4. dry with materialafter drying with sodium sulfate

ORD record

ord-c5ebfe6e19984f1aabaa307bac8ba7d0

Source dataset

uspto-grants-1997_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05616705