Bromoacetic Acid → HCID 57464135, compound
Reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N:3]=1.[Br:11][CH2:12][C:13]([OH:15])=[O:14]>CN(C=O)C>[Br-:11].[C:6]([C:5]1[CH:9]=[CH:10][C:2]([CH3:1])=[N+:3]([CH2:12][C:13]([OH:15])=[O:14])[CH:4]=1)(=[O:7])[NH2:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 6-methyl nicotinamide (400 mg, 2.94 mmol, 1.0 eq) and bromoacetic acid (408 mg, 2.94 mmol, 1.0 eq) in DMF (10 mL) was stirred at room temperature for 6 days. The reaction mixture was monitored by LCMS. Solvent was then evaporated and the crude product was purified by preparative HPLC to afford 136 mg of the expected compound.
Workup
- customSolvent was then evaporated
- customthe crude product was purified by preparative HPLC
Sources & evidence
- ORD record
- ord-39ef5d97b9714a36beeb8d097ff32db6
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09346799B2
Reaction notes
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