Triethylamine → 4-(1H-1,2,4-Triazol-1-yl)phenyl 1,1,1-trifluoromethanesulfonate

HRID 532500Notes

Reaction equation

HRID 532500 reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=2)[CH:5]=[N:4][CH:3]=[N:2]1.C(N(CC)CC)C.[O:20](S(C(F)(F)F)(=O)=O)[S:21]([C:24]([F:27])([F:26])[F:25])(=O)=[O:22]>ClCCl>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([O:12][S:21]([C:24]([F:27])([F:26])[F:25])(=[O:22])=[O:20])=[CH:10][CH:11]=2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 67749Trifluoromethanesulfonic anhydrideHCID 1100644-(1,2,4-Triazol-1-yl)phenol

Product 1

HCID 866131654-(1H-1,2,4-Triazol-1-yl)phenyl 1,1,1-trifluoromethanesulfonate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.0 g of 4-[1,2,4]triazol-1-yl-phenol was dissolved in 10 ml of dichloromethane, and 1.72 ml of triethylamine was added thereto. 1.56 ml of Tf2O was added to the mixture and stirred for 5 hr. The reaction was terminated by using water, and the resulting mixture was extracted with dichloromethane, dried over anhydrous sodium sulfate, and concentrated under a reduced pressure to obtain the title compound.

Workup

  1. customThe reaction was terminated
  2. extractionthe resulting mixture was extracted with dichloromethane
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under a reduced pressure

Sources & evidence

ORD record
ord-0accd0b89165430a8f7a88ff3ae105a5
Source dataset
uspto-grants-2014_10
Patent number
US08853213B2

Reaction notes

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