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Hydrochloric Acid → HCID 67776011, compound

HRID 533396
Notes
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Reaction equation

HRID 533396 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([C:20]([O:22]C)=[O:21])[CH:18]=2)[CH:13]=[CH:12][N:11]=1.[OH-].[Na+].C1COCC1.[ClH:31]>C(O)C>[ClH:31].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([C:20]([OH:22])=[O:21])[CH:18]=2)[CH:13]=[CH:12][N:11]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 67772403HCID 67772403, compound

Product 1

HCID 67776011HCID 67776011, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of methyl 1-(2,4,6-trifluorophenyl)isoquinoline-7-carboxylate (228 mg), a 1M aqueous sodium hydroxide solution (4 mL), THF (3 mL), and ethanol (3 mL) was stirred at room temperature for 24 hours. The reaction mixture was neutralized with 1M hydrochloric acid, and the precipitate was collected by filtration to obtain 1-(2,4,6-trifluorophenyl)isoquinoline-7-carboxylic acid hydrochloride (200 mg).

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-e1ea61e8ba9040869644c9244f966f7f
Source dataset
uspto-grants-2014_10
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08853242B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes