Ethyl formate → Formamide

HRID 53364

Reaction equation

[CH:1]([O:3][CH2:4][CH3:5])=[O:2].[C:6]([CH2:9][CH:10](C)[C:11]([O:13][CH3:14])=[O:12])(=[O:8])[NH2:7]>>[CH3:14][O:13][C:11](=[O:12])[CH2:10][CH:9]([CH3:6])[C:1]([O:3][CH2:4][CH3:5])=[O:2].[CH:6]([NH2:7])=[O:8]

Participants

Reactant 2

HCID 8025Ethyl formate

HCID 11768702Methyl 3-carbamoylisobutyrate

Product 2

HCID 713Formamide

HCID 54001611Methylsuccinic acid ethyl methyl ester

Procedure

The procedure in Example 3 (3) was repeated except that ethyl formate was used in place of methyl formate. As a result, the conversion of methyl 3-carbamoylisobutyrate was 83.7% and there were obtained methylsuccinic acid ethyl methyl ester at a selectivity of 99.8% and formamide at a selectivity of 98.6%, each based on the reacted methyl 3-carbamoylisobutyrate.

Sources & evidence

ORD record: ord-0b2414389f2d435ebd782a575159d2a6
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05618953

Linked notes

Loading…