Iodoform → 1-Oxo-1-(4-chlorophenyl)-3-iodo-2-propene
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH:10]=O)=[O:9])=[CH:4][CH:3]=1.[CH:12](I)(I)[I:13]>O1CCCC1.[Cl-].[Cl-].[Cr+2]>[O:9]=[C:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH:10]=[CH:12][I:13]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
This compound is prepared in a manner analogous to that of Step C of Example 4, using 6.7 grams (0.04 mole) of 4-chlorophenylglyoxal (prepared by the method of Kornblum et al., JACS, (1957), 79, 6562), 29.5 grams (0.24 mole) of anhydrous chromium(II) dichloride, and 31.5 grams (0.08 mole) of iodoform in 600 mL of tetrahydrofuran, yielding 1-oxo-1-(4-chlorophenyl)-3-iodo-2-propene.
Workup
- customThis compound is prepared in a manner analogous to that of Step C of Example 4
Sources & evidence
- ORD record
- ord-96efb8b9fa07495b9c0fddd1bf2d549f
- Source dataset
- uspto-grants-1997_04
- Patent number
- US05622954
Reaction notes
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