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Hydrochloric Acid → 3,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole hydrochloride

HRID 542869
Notes
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Reaction equation

HRID 542869 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[C:13]([CH2:23][CH3:24])=[N:12][N:11]=2)=[CH:6][CH:5]=1.C(OC(C)C)(C)C>C(O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[C:13]([CH2:23][CH3:24])=[N:12][N:11]=2)=[CH:8][CH:9]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 130540183,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole

Product 1

HCID 201515453,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

2.9 ml of a solution of 5.9N hydrogen chloride in ethanol were added to a solution of 5 g of the product of Example 1 in 5 ml of ethanol and the mixture was stirred while adding isopropyl ether thereto. The mixture was stirred for 24 hours and was filtered. The product was empasted with isopropyl ether, filtered and dried under pressure to obtain 4.4 g of 3,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole hydrochloride.

Workup

  1. stirringThe mixture was stirred for 24 hours
  2. filtrationwas filtered
  3. filtrationfiltered
  4. customdried under pressure

Sources & evidence

ORD record
ord-443474a511404915bd3fcb8dc9d678f8
Source dataset
uspto-grants-1987_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04659729

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes