Water → HCID 23712813, compound
Reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([O:12]CC)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].O.[OH-].[Li+:17]>O1CCCC1>[CH:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10]([O-:12])=[O:11])[CH2:8][CH2:9]1)([CH3:3])[CH3:2].[Li+:17]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Ethyl 1-isopropylpiperidine-4-carboxylate (Farmaco., 1993, Vol. 48, p. 1439) (3.43 g) was dissolved in tetrahydrofuran (60 ml), and water (15 ml) and lithium hydroxide (421 mg) were added at room temperature to stir the mixture overnight. The reaction mixture was concentrated under reduced pressure to obtain the title compound (3.05 g) as a white solid.
Workup
- concentrationThe reaction mixture was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-fd84500ac5724f2d998a5236c197f6d9
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07935824B2
Reaction notes
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