Reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]#[N:11].CC(C)([O-])C.[K+].Br[CH2:21][CH2:22][CH2:23][Cl:24]>C1COCC1>[Cl:24][CH2:23][CH2:22][CH2:21][CH:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:12])([F:13])[F:1])[C:10]#[N:11]Participants
Conditions
- Temperature
- -10 °C
Procedure
(2-Trifluoromethylphenyl)acetonitrile (12.47 g, 67.3 mmol) was dissolved in THF (87.3 mL) at room temperature under nitrogen atmosphere. The reaction solution was cooled to −10° C. Then, potassium tert-butoxide (7.93 g, 70.7 mmol) was added to the reaction solution and the reaction mixture was stirred at −10° C. for 10 minutes. 1-Bromo-3-chloropropane (6.99 mL, 70.7 mmol) was added dropwise to the reaction mixture over 14 minutes, and the reaction mixture was stirred at 0° C. for 2 hours. The reaction was quenched with 10% NH4Cl aq. (8.6 mL). After the mixture was stirred, the aqueous layer was separated. The organic layer was concentrated under the reduced pressure to obtain the title compound (23.24 g). The yield was calculated as over 99% by HPLC external standard method.
Workup
- stirringthe reaction mixture was stirred at 0° C. for 2 hours
- customThe reaction was quenched with 10% NH4Cl aq. (8.6 mL)
- stirringAfter the mixture was stirred
- customthe aqueous layer was separated
- concentrationThe organic layer was concentrated under the reduced pressure
Sources & evidence
- ORD record
- ord-d045f116488943008215e35a9e10d823
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07935815B2
Linked notes
Loading…