[CH3:1][NH:2][CH3:3].[C:4](O)(=O)C.C=O.[C:10]1([C:16]2[NH:24][C:19]3=[N:20][CH:21]=[CH:22][N:23]=[C:18]3[CH:17]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>O1CCCC1.C(OCC)(=O)C>[CH3:1][N:2]([CH3:4])[CH2:3][C:17]1[C:18]2[C:19](=[N:20][CH:21]=[CH:22][N:23]=2)[NH:24][C:16]=1[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1A solution of dimethylamine in tetrahydrofuran (0.5 mL, 2.0M) at 0° C. was treated with glacial acetic acid (15 μl) then with formaldehyde (75 μl, 40% solution). After stirring at 0° C. for 10 minutes this mixture was treated with 6-phenyl-5H-pyrrolo[2,3-b]pyrazine [0.195 g, Example 2(c)] and then with tetrahydrofuran (3 mL) to ensure complete dissolution. The reaction mixture was allowed to warm to ambient temperature, then stirred overnight, then diluted with ethyl acetate (5 mL) and then extracted three times with hydrochloric acid (5 mL, 1N). The combined acid extracts were adjusted to pH 6-7 by addition of potassium hydroxide solution (5N). The resulting pale yellow solid was filtered, then washed with water and then dried to give the title compound (0.16 g) as a pale yellow solid, m.p. 191-192° C.
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