Sodium hydride → 2-Chloro-4-methyl-6-(3-thienylmethyloxy)pyridine
Reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][OH:7])=[CH:2]1.[H-].[Na+].[Cl:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13](Cl)[N:12]=1>O1CCCC1>[Cl:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([O:7][CH2:6][C:3]2[CH:4]=[CH:5][S:1][CH:2]=2)[N:12]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution containing 3-thiophenemethanol (0.78 g, 0.0062×1.1 mol) and sodium hydride (0.26 g, (ca.60% in mineral oil), 0.0062×1.05 mol) in tetrahydrofuran, 2,6-dichloro-4-methylpyridine (1.0 g, 0.0062 mol) was added, and the resultant solution was refluxed for about 1 hour.
Workup
- additionwas added
Sources & evidence
- ORD record
- ord-be95cbbb0289473d8b925f0d6908ded9
- Source dataset
- uspto-grants-1997_04
- Patent number
- US05624942
Reaction notes
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