Phosphorus oxychloride → 4-Thiazoleacetonitrile, 2-amino-
Reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([NH2:10])=O)[N:6]=1.P(Cl)(Cl)(Cl)=O>CN(C=O)C>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]#[N:10])[N:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2.0 g (13.0 mmol) of 2-(2-Amino-thiazol-4-yl)-acetamide in 30 ml of dry DMF was added Phosphorus oxychloride (2.3 ml, 25.0 mmol, 2.0 equiv.) dropwise at 0° C.
Sources & evidence
- ORD record
- ord-96323deaafd94ef2a0bb7a3f45f00494
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07951824B2
Reaction notes
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