Nitrogen → 2-Furanpropanol, tetrahydro-

HRID 56216

Reaction equation

HRID 56216 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][CH2:7][C:8](O)=[O:9].B.N#N>C1COCC1>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][CH2:7][CH2:8][OH:9]

Participants

5

Reactant 3

HCID 947NitrogenHCID 6331BoraneHCID 2631613-(Oxolan-2-yl)propanoic acid

Product 1

HCID 130202-Furanpropanol, tetrahydro-

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 3-(tetrahydrofuran-2-yl)propanoic acid (11.5 g, 80.0 mmol) in anhydrous THF (200 mL) was added borane (160 mL, 160 mmol, 1 mol/L in THF) dropwise under N2 and the mixture was stirred at rt overnight. The reaction mixture was quenched with MeOH and concentrated in vacuo to give the title compound, which was used for next step without further purification.

Workup

  1. customThe reaction mixture was quenched with MeOH
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-7a75b33b4b474dd5a6abbe7fc9ad701c
Source dataset
uspto-grants-2016_09
Patent number
US09434695B2

Linked notes

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