Oxalic acid dihydrate → 5,6-Dimethylquinoxaline-2,3-diol
Reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([NH2:9])[C:3]=1[NH2:10].O.O.[C:13](O)(=[O:17])[C:14](O)=[O:15]>Cl>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:10][C:13](=[O:17])[C:14](=[O:15])[NH:9]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
To a solution of 3,4-dimethyl-benzene-1,2-diamine (67.5 g, 496 mmol) in 5N HCl (250 mL) was added oxalic acid dihydrate (69.3 g, 550 mmol). The reaction mixture was heated to 100° C. under stirring. The reaction mixture was stirred for 8 hours and cooled to room temperature. The dark precipitate was filtered, washed, and dried.
Workup
- stirringThe reaction mixture was stirred for 8 hours
- temperaturecooled to room temperature
- filtrationThe dark precipitate was filtered
- washwashed
- customdried
Sources & evidence
- ORD record
- ord-17f758d794f04d80b8d1500a87be0bd7
- Source dataset
- uspto-grants-2001_01
- Patent number
- US06172065B2
Reaction notes
Loading…