HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Stannous chloride dihydrate → 4-Hydrazino-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid hydrochloride

HRID 565809
Notes
Print preview

Reaction equation

HRID 565809 reaction equation
[N:1]([O-])=O.[Na+].[NH2:5][C:6]1[C:15]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=2[C:9]([C:16]([OH:18])=[O:17])=[CH:8][CH:7]=1.O.O.[Cl:21][Sn]Cl>O.Cl>[ClH:21].[NH:5]([C:6]1[C:15]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=2[C:9]([C:16]([OH:18])=[O:17])=[CH:8][CH:7]=1)[NH2:1]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 61436Stannous chloride dihydrateHCID 221117984-Amino-5,6,7,8-tetrahydronaphthalene-1-carboxylic acidHCID 23668193Sodium Nitrite

Product 1

HCID 702454754-Hydrazino-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid hydrochlorideYield 73.3%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolvent
2×
HCID 962WaterSolvent

Conditions

Temperature
-5 °C

Procedure

A solution of 0.26 g of NaNO2 in 1 ml of water is added to a solution, cooled to −5° C., of 0.73 g of 4-amino-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid in 10 ml of concentrated HCl. After one and a half hours of stirring at −5° C., a solution of 3.4 g of SnCl2.2H2O in 34 ml of concentrated HCl is added at −5° C. The mixture is stirred for 1 hour at RT and filtered, and the product is washed with concentrated HCl and dried under a stream of dry nitrogen to obtain 0.67 g of the expected hydrazine.

Workup

  1. stirringThe mixture is stirred for 1 hour at RT
  2. filtrationfiltered
  3. washthe product is washed with concentrated HCl
  4. customdried under a stream of dry nitrogen

Sources & evidence

ORD record
ord-6f19461724064ba8a55e84cfcad118cb
Source dataset
uspto-grants-2001_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06172239B2

Reaction notes

Loading…

On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes