1-Benzyl-3-methyl-5-nitroindazole → 1-Benzyl-3-methyl-1H-indazol-5-ylamine

HRID 566381Notes

Reaction equation

HRID 566381 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([N+:17]([O-])=O)=[CH:14][CH:15]=2)[C:10]([CH3:20])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C1COCC1.[Pt]>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=2)[C:10]([CH3:20])=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 219521621-Benzyl-3-methyl-5-nitroindazoleHCID 178418361HCID 178418361, compound

Product 1

HCID 541033091-Benzyl-3-methyl-1H-indazol-5-ylamine

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

1-Benzyl-3-methyl-5-nitroindazole (0.15 g) in THF (15 ml) was treated with platinum on carbon (0.05 g, 5%) under an atmosphere of hydrogen at room temperature. When hydrogen uptake was complete, the mixture was filtered and concentrated in vacuo to give the title compound; m/z (M+1)+268.

Workup

  1. filtrationthe mixture was filtered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-8346621a1d504e8aa5dc65eef9f7818f
Source dataset
uspto-grants-2001_01
Patent number
US06174889B1

Reaction notes

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