Diisobutylaluminum hydride → 1-Benzofuran-5-ylmethanol
Reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10](OC)=[O:11])=[CH:9][C:4]=2[CH:3]=[CH:2]1.CC(C[AlH]CC(C)C)C>O1CCCC1>[OH:11][CH2:10][C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH:2]=[CH:3][C:4]=2[CH:9]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
5.8 g (32.9 mmol) of methyl benzofuran-5-carboxylate are stirred analogously to Example 1 g in 50 ml of tetrahydrofuran with 64.5 ml (98.6 mmol) of DIBAL (1.53 molar) at -70° C. overnight.
Sources & evidence
- ORD record
- ord-56d5422270d2469fa3a6d570c7cb9e7e
- Source dataset
- uspto-grants-1988_03
- Patent number
- US04734407
Reaction notes
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