1,3-Dibromopropane → HCID 66728202, compound

Reaction equation

[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:15]3=[N:16][CH:17]=[CH:18][CH:19]=[C:14]3[NH:13][CH:12]=2)=[CH:7][CH:6]=1.[H-].[Na+].[Br:22][CH2:23][CH2:24][CH2:25]Br>O>[Br:22][CH2:23][CH2:24][CH2:25][N:13]1[C:14]2[C:15](=[N:16][CH:17]=[CH:18][CH:19]=2)[C:11]([C:8]2[CH:7]=[CH:6][C:5]([O:4][CH2:3][O:2][CH3:1])=[CH:10][CH:9]=2)=[CH:12]1

Participants

Procedure

To a solution of 3-[4-(methoxymethoxy)phenyl]-1H-pyrrolo[3,2-b]pyridine (650 mg) was added NaH (60% in oil, 153 mg) at 0° C. After stirring at room temperature for 1 h, the mixture was added dropwise to 1,3-dibromopropane (0.778 mL). The mixture was stirred at room temperature for 2 h. The mixture was added to water and extracted with AcOEt. The organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (486 mg).