[OH:1][CH2:2][CH2:3][N:4]([CH3:36])[C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:20]=[C:19]([NH:21][CH2:22][C@H:23]3[O:28][CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24]3)[C:18]3[C:13](=[N:14][CH:15]=[CH:16][N:17]=3)[CH:12]=2)=[CH:7][CH:6]=1.Cl>CC(=O)OCC>[CH3:36][N:4]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[N:20]=[C:19]([NH:21][CH2:22][C@H:23]3[O:28][CH2:27][CH2:26][NH:25][CH2:24]3)[C:18]3[C:13](=[N:14][CH:15]=[CH:16][N:17]=3)[CH:12]=2)=[CH:9][CH:10]=1)[CH2:3][CH2:2][OH:1](R)-tert-butyl 2-((7-(4-((2-hydroxyethyl)(methyl)amino)phenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)morpholine-4-carboxylate was dissolved in EA (20 mL), 5M HCl in EA (10 mL) was added, the mixture was stirred at room temperature overnight. It was concentrated, treated with NH3.H2O, concentrated, purified by preparative TLC to give 10 mg reddish-brown solid. MS (m/z): 395 (M+H)+
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