Methyl 2-bromopropionate → HCID 14326200, compound
Reaction equation
[CH2:1]([NH2:4])[C:2]#[CH:3].Br[CH:6]([CH3:11])[C:7]([O:9][CH3:10])=[O:8].C(=O)(O)[O-].[Na+]>O>[CH2:1]([NH:4][CH:6]([CH3:11])[C:7]([O:9][CH3:10])=[O:8])[C:2]#[CH:3]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
Into a 250 ml round bottom flask are placed 26 g (0.47 mole) of propargylamine, 78.8 g (0.47 mole) of methyl 2-bromopropionate, and 39.7 g (0.47 mole) of sodium bicarbonate. The reaction mixture is heated at 80° C. overnight. It is cooled and poured into 200 ml of water. Extraction with ether provides 45 g of crude product which is further purified by vacuum distillation (94°-95°/3 mm) to give 25 g of desired product.
Workup
- customInto a 250 ml round bottom flask are placed
- temperatureIt is cooled
- extractionExtraction with ether
- customprovides 45 g of crude product which
- distillationis further purified by vacuum distillation (94°-95°/3 mm)
Sources & evidence
- ORD record
- ord-1eb52b5292e24d0a924fb1dbea791c72
- Source dataset
- uspto-grants-1988_06
- Patent number
- US04753957
Reaction notes
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