Lithium hydroxide, monohydrate → HCID 178524764, compound

Ethyl 4-hydroxypyrimidine-5-carboxylate can be prepared following the procedure of M. Pesson et al., Eur. J. Med. Chem.—Chim. Ther. 1974, 9, 585. A solution of this ester (500 mg, 3 mmol) in THF (10 mL) and MeOH (5mL) was treated with LiOH.H2O (373 mg, 8.9 mmol) and stirred overnight. The mixture was quenched with conc. HCl (1 mL) and extracted with EtOAc (2×20 mL). The combined organic extract was dried (MgSO4) and concentrated to give 260 mg of the title compound 19 as an orange solid, m.p. 220° C. (dec). 4-Hydroxy-2-methylpyrimidine-5-carboxylic Acid (20).

1. customThe mixture was quenched with conc. HCl (1 mL)
2. extractionextracted with EtOAc (2×20 mL)
3. extractionThe combined organic extract
4. dry with materialwas dried (MgSO4)
5. concentrationconcentrated

ORD record

ord-fa8220878f0a4f129f5a879f952e56e9

Source dataset

uspto-grants-2005_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06927225B2