Sodium Sulfite → Ethyl(6-((2,4-dichlorobenzyl)oxy)-1,1-dioxido-1-benzothiophen-3-yl)acetate

Temperature

25 °C

To a mixture of ethyl(6-((2,4-dichlorobenzyl)oxy)-1-benzothiophen-3-yl)acetate (10.0 g) in anhydrous DCM (400 mL) was added mCPBA (85%, 15.7 g), and the resulting solution was stirred at 25° C. for 3 d. To the reaction mixture was added Na2SO3 (30.0 g), and the mixture was stirred at 25° C. for 0.5 h. The reaction mixture was washed successively with saturated aqueous NaHCO3 and brine, dried over Na2SO4 and concentrated in vacuo. The residue was washed with EtOAc to give the title compound (8.50 g).

1. stirringthe mixture was stirred at 25° C. for 0.5 h
2. washThe reaction mixture was washed successively with saturated aqueous NaHCO3 and brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated in vacuo
5. washThe residue was washed with EtOAc

ORD record

ord-054e05d73d354d4b90f96785e676bf3d

Source dataset

uspto-grants-2016_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09238639B2