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Ethyl Thioglycolate → HCID 89767819, compound

HRID 591477
Notes
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Reaction equation

HRID 591477 reaction equation
[Cl:1][C:2]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:3]=1[CH2:4][O:5][C:6]1[CH:16]=[CH:15][C:9]([C:10]([O:12]CC)=O)=[C:8](F)[CH:7]=1.O.[OH-].[Li+].[SH:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29]>CN(C=O)C.O>[Cl:1][C:2]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:3]=1[CH2:4][O:5][C:6]1[CH:16]=[CH:15][C:9]2[C:10]([OH:12])=[C:27]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[S:26][C:8]=2[CH:7]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 12185Ethyl ThioglycolateHCID 168937Lithium hydroxide, monohydrateHCID 89768166HCID 89768166, compound

Product 1

HCID 89767819HCID 89767819, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228Dimethylformamide
Solvent

Procedure

To a mixture of ethyl 4-((2,4-dichlorobenzyl)oxy)-2-fluorobenzoate (2.0 g) in DMF (dry) (40 mL) were added lithium hydroxide monohydrate (0.978 g) and ethyl 2-mercaptoacetate (1.92 mL) at room temperature. The mixture was stirred at room temperature for 2 d. The mixture was diluted with water and the precipitate was collected by filtration, and washed with IPE to give the title compound (2.30 g).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washwashed with IPE

Sources & evidence

ORD record
ord-3a9d1a82e5af40f49aa399d08a6fe68c
Source dataset
uspto-grants-2016_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09238639B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes