Oxalyl chloride → 2-Chloro-6-methylbenzoyl isocyanate

HRID 59272

Reaction equation

HRID 59272 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:13](Cl)=[O:14]>C(Cl)CCl>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4]([N:6]=[C:13]=[O:14])=[O:5]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 113589Benzamide, 2-chloro-6-methyl-

Product 1

HCID 900195972-Chloro-6-methylbenzoyl isocyanateYield 86.7%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 2-chloro-6-methylbenzamide (1.0 g, 5.9 mmol), oxalyl chloride (0.894 g, 7.1 mmol) and EDC (20 mL) to afford 1.00 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-1eea1c649c4e4c389264d24d65d8cc40
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Linked notes

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