Hydrochloric Acid → 3-(Difluoromethyl)aniline
Reaction equation
[F:1][CH:2]([F:12])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-])=O)[CH:4]=1.Cl>[Fe].CO>[F:1][CH:2]([F:12])[C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[NH2:9]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
The title compound was prepared according to the procedure described in step-2 of Intermediate-28 by using 1-(difluoromethyl)-3-nitrobenzene (1.0 g, 5.0 mmol), Iron powder (3.0 g, 15.0 mmol), conc. HCl (5 mL) and methanol (20 mL) to afford 0.700 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 5.36 (br s, 2H), 6.62-6.82 (m, 4H), 7.11 (t, J=7.8 Hz, 1H); MS (m/z): 144.05 (M+H)+.
Workup
- customThe title compound was prepared
Sources & evidence
- ORD record
- ord-7536efb602ec4e8796fc671ff4414099
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09439890B2
Reaction notes
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