Oxalyl chloride → 4-Trifluoromethylbenzoylisocyanate

HRID 59349

Reaction equation

HRID 59349 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[O:8])=[CH:5][CH:4]=1.C(Cl)(=O)[C:15](Cl)=[O:16]>C(Cl)CCl>[F:1][C:2]([F:12])([F:13])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([N:9]=[C:15]=[O:16])=[O:8])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 746844-(Trifluoromethyl)benzamide

Product 1

HCID 149137444-Trifluoromethylbenzoylisocyanate

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 4-(trifluoromethyl)benzamide (0.200 g, 1.05 mmol), EDC (10 mL) and oxalyl chloride (0.15 mL, 1.58 mmol) to afford 0.200 g of the product.

Sources & evidence

ORD record
ord-b2534da991cd4134881a42bbc768ab7f
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Linked notes

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