Oxalyl chloride → 3-Fluoro-4-(trifluoromethyl)benzoyl isocyanate

HRID 59403

Reaction equation

HRID 59403 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12])[C:5]([NH2:7])=[O:6].C(Cl)(=O)[C:16](Cl)=[O:17]>C(Cl)CCl>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]([F:12])([F:13])[F:14])[C:5]([N:7]=[C:16]=[O:17])=[O:6]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 27375433-Fluoro-4-(trifluoromethyl)benzamide

Product 1

HCID 900198623-Fluoro-4-(trifluoromethyl)benzoyl isocyanate

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 3-fluoro-4-(trifluoromethyl)benzamide (0.200 g), oxalyl chloride (0.025 mL) and EDC (15 mL) to afford 0.150 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-d06a62af6f2c4e188397f9c031e4e59d
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Linked notes

Loading…