Oxalyl chloride → 4-(Bromomethyl)benzoyl isocyanate
Reaction equation
[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[O:8])=[CH:5][CH:4]=1.C(Cl)(=O)[C:13](Cl)=[O:14]>C(Cl)CCl>[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([N:9]=[C:13]=[O:14])=[O:8])=[CH:5][CH:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 4-(bromomethyl)benzamide (0.200 g), oxalyl chloride (0.012 mL) and EDC (15 mL) to afford 0.150 g of the desired product.
Workup
- customThe title compound was prepared
Sources & evidence
- ORD record
- ord-407fd253c6b44db9b13486776b9d965c
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09439890B2
Reaction notes
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