Dimethylformamide → 1-Methyl-2-(5-aminomethylhexylisoxazol-3-yl)-5-nitroimidazole

HRID 596205

Reaction equation

C(Cl)CCCCC.[CH3:8][N:9]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][N:11]=[C:10]1[C:17]1[C:21]([CH2:22][CH2:23][CH2:24][CH2:25][CH:26]([CH2:28]CN)[CH3:27])=[CH:20][O:19][N:18]=1.C[N:32](C)C=O>>[CH3:8][N:9]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][N:11]=[C:10]1[C:17]1[C:21]([CH2:22][CH2:23][CH2:24][CH2:25][CH:26]([CH2:28][NH2:32])[CH3:27])=[CH:20][O:19][N:18]=1

Participants

Reactant 3

HCID 6228Dimethylformamide

HCID 109921-Chlorohexane

HCID 681205621-Methyl-2-(5-aminoethylhexylisoxazol-3-yl)-5-nitroimidazole

Product 1

HCID 203624761-Methyl-2-(5-aminomethylhexylisoxazol-3-yl)-5-nitroimidazole

Procedure

The product prepared above is treated in a similar fashion with hexyl chloride in dimethylformamide for 2 hours. The recrystallized product is identified as 1-methyl-2-(5-aminoethylhexylisoxazol-3-yl)-5-nitroimidazole.

Workup

customThe product prepared

Sources & evidence

ORD record: ord-689eb3082301414b975a2d0afb36a4f0
Source dataset: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04010176

Linked notes

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