Hydrochloric Acid → 1-(2-(2-(1-Benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinol hydrochloride

HRID 597806Notes

Reaction equation

HRID 597806 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]3[CH2:18][CH:17]([OH:19])[CH2:16]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1.[ClH:20]>C(OCC)(=O)C>[ClH:20].[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]3[CH2:18][CH:17]([OH:19])[CH2:16]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 114042301-(2-(2-(1-Benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinol

Product 1

HCID 114042291-(2-(2-(1-Benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinol hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

1.03 g of 1-(2-(2-(1-benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinol was dissolved in 4.2 ml of ethyl acetate. Thereafter, 0.86 ml of an ethyl acetate solution containing 4.76 mol/l dry hydrogen chloride was added to the obtained solution, and the obtained mixture was stirred at a room temperature for 1 hour, and then at 5° C. for 1 hour. Thereafter, precipitated crystals were collected by filtration, washed with ethyl acetate, and then dried, so as to obtain 0.98 g of 1-(2-(2-(1-benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinol hydrochloride.

Workup

  1. additionwas added to the obtained solution
  2. waitat 5° C. for 1 hour
  3. customThereafter, precipitated crystals
  4. filtrationwere collected by filtration
  5. washwashed with ethyl acetate
  6. customdried

Sources & evidence

ORD record
ord-3374cb4c4ade42af9da5c99d4b443c42
Source dataset
uspto-grants-2011_03
Patent number
US07897594B2

Reaction notes

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