C([N:8]1[C:16]2[C:15]3=[N:17][N:18]=[CH:19][N:14]3[C:13](=[O:20])[N:12]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[C:11]=2[N:10]=[CH:9]1)C1C=CC=CC=1.Cl>C(O)(=O)C.[OH-].[Pd+2].[OH-]>[CH2:21]([N:12]1[C:11]2[N:10]=[CH:9][NH:8][C:16]=2[C:15]2=[N:17][N:18]=[CH:19][N:14]2[C:13]1=[O:20])[CH2:22][CH2:23][CH2:24][CH3:25]To a mixture of 9-benzyl-6-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[3,4-i]purin-5-one (0.25 g, 0.74 mmol) in acetic acid (20 mL) was added palladium hydroxide (0.20 g, 1.4 mmol) under N2. The mixture was shaken under H2 at 60 psi overnight. Since the reaction was not complete, more palladium hydroxide (0.2 g, 1.4 mmol) and concentrated HCl (1 mL) were added. The resulting mixture was shaken under H2 at 60 psi overnight. The reaction solution was filtered and the filtrate was concentrated under vacuum to provide the product as a white solid (0.12 g, 65.6%). LCMS calculated for C11H15N6O (M+H): 247.1. found: 247.1.
Loading…
