Diisopropylethylamine → Methyl 2-amino-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylate

Ethoxycarbonyl isothiocyanate (9.0 g) was added to a 1,4-dioxane (100 ml) suspension of 2-aminopyridine-4-carboxylic acid methyl ester (10 g) at an internal temperature of 19° C. to 23° C. over 20 minutes. The obtained mixture was stirred for 90 minutes at the same temperature as described above, and was then concentrated under reduced pressure to obtain a crude product. The obtained crude product was added to a mixed suspension of methanol (70 ml) and ethanol (70 ml) containing hydroxyamine hydrochloride (22.8 g) and diisopropylethylamine (34 ml), and thereafter, the reaction solution was stirred at room temperature for 67 hours, at 60° C. for 5 hours, and again, at room temperature for 20 hours. Thereafter, the generated solid was collected, and it was washed with ethanol (30 ml) and was then dried, so as to obtain the title compound (11.3 g) in the form of a white solid.

1. concentrationwas then concentrated under reduced pressure
2. customto obtain a crude product
3. customThe obtained crude product
4. stirringthe reaction solution was stirred at room temperature for 67 hours, at 60° C. for 5 hours
5. waitagain, at room temperature for 20 hours
6. customThereafter, the generated solid was collected
7. washit was washed with ethanol (30 ml)
8. customwas then dried

ORD record

ord-40048a9e96304c19886aee2f1c61a747

Source dataset

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09440970B2