4-Chloro-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carboxylic acid → 4-Chloro-9H-dipyrido[2,3-b;4',3'-d]pyrrole

HRID 60258

Reaction equation

HRID 60258 reaction equation
[Cl:1][C:2]1[C:10]2[C:9]3[CH:11]=[C:12](C(O)=O)[N:13]=[CH:14][C:8]=3[NH:7][C:6]=2[N:5]=[CH:4][CH:3]=1>CN1CCCC1.CN1C(=O)CCC1>[Cl:1][C:2]1[C:10]2[C:9]3[CH:11]=[CH:12][N:13]=[CH:14][C:8]=3[NH:7][C:6]=2[N:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 583650834-Chloro-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carboxylic acid

Product 1

HCID 583650494-Chloro-9H-dipyrido[2,3-b;4',3'-d]pyrrole

Reagents, catalysts & solvents 2

HCID 84541-MethylpyrrolidineSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A mixture of 4-chloro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carboxylic acid (390 mg, 1.57 mmol) in N-methylpyrrolidine (8 mL) was heated under reflux for 8 hours. The mixture was allowed to cool to ambient temperature. The compound was used as a solution in NMP for subsequent reactions. LCMS (Method B): RT=2.15 min, M+H+=204.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 8 hours

Sources & evidence

ORD record
ord-65e1ba1981d541f8b32d7f51f50d36d3
Source dataset
uspto-grants-2016_09
Patent number
US09440976B2

Linked notes

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