Water → N-(1-(1-Cyclopropyl-1-oxopropan-2-yl)-5-iodopyridin-2(1H)-ylidene)-4-methylbenzenesulfonamide

To a solution of N-(5-iodopyridin-2-yl)-4-methylbenzenesulfonamide (33.1 g) in DMF (400 mL) was added sodium hydride (60% oil dispersion, 3.89 g) at 0° C., and the mixture was stirred at room temperature for 30 min. Then 2-bromo-1-cyclopropylpropan-1-one (23.5 g) was added to the obtained mixture, and the mixture was stirred at room temperature overnight. The reaction mixture was poured into water and extracted with ethyl acetate. The obtained organic layer was washed with brine, dried over magnesium sulfate, and concentrated in vacuo. The resulting solid was suspended in diisopropyl ether, the suspension was stirred for 1 hr, and the solid was collected by filtration. The obtained solid was dissolved in ethyl acetate (1100 mL) at 70° C., and hexane (400 mL) was dropwise added at 60° C. The mixture was allowed to cool to room temperature overnight. The resulting precipitate was collected by filtration, washed with hexane/ethyl acetate (1/1) 3 times, and dried to give the title compound (30.5 g) as a white solid.

1. stirringthe mixture was stirred at room temperature overnight
2. extractionextracted with ethyl acetate
3. washThe obtained organic layer was washed with brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated in vacuo
6. stirringthe suspension was stirred for 1 hr
7. filtrationthe solid was collected by filtration
8. dissolutionThe obtained solid was dissolved in ethyl acetate (1100 mL) at 70° C.
9. additionhexane (400 mL) was dropwise added at 60° C
10. temperatureto cool to room temperature overnight
11. filtrationThe resulting precipitate was collected by filtration
12. washwashed with hexane/ethyl acetate (1/1) 3 times
13. customdried

ORD record

ord-24460f0c3d8649ab9dbbf6b688a11504

Source dataset

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09440987B2