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Hydrochloric Acid → N,N-dimethyl-[5-[4-(3,5-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611295
Notes
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Reaction equation

HRID 611295 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:31])[C:15]3[CH:20]=[CH:19][C:18]([C:21](=[O:30])[C:22]4[CH:27]=[C:26]([Cl:28])[CH:25]=[C:24]([Cl:29])[CH:23]=4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].Cl>CO.C(OCC)(=O)C>[ClH:28].[CH3:3][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:31])[C:15]3[CH:20]=[CH:19][C:18]([C:21](=[O:30])[C:22]4[CH:23]=[C:24]([Cl:29])[CH:25]=[C:26]([Cl:28])[CH:27]=4)=[CH:17][CH:16]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:1]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19599901N,N-dimethyl-[5-[4-(3,5-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine

Product 1

HCID 19600049N,N-dimethyl-[5-[4-(3,5-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent
HCID 8857
Ethyl Acetate
Solvent

Procedure

N,N-Dimethyl-[5-[4-(3,5-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.200 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This was concentrated and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis was concentrated
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-e17fc44dc09d40e9b3c392ae86b4eb8a
Source dataset
uspto-grants-1999_12
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05998433

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes