Ammonium Hydroxide → 2-(2-Phenyl-1-propoxy)acetamide

HRID 613755

Reaction equation

HRID 613755 reaction equation
[C:1]1([CH:7]([CH3:14])[CH2:8][O:9][CH2:10][C:11](O)=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(Cl)(=O)C(Cl)=O.[OH-].[NH4+:22]>C1(C)C=CC=CC=1>[C:1]1([CH:7]([CH3:14])[CH2:8][O:9][CH2:10][C:11]([NH2:22])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 14923Ammonium HydroxideHCID 65578Oxalyl chlorideHCID 187790482-(2-Phenylpropoxy)acetic acid

Product 1

HCID 187790372-(2-Phenyl-1-propoxy)acetamide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The subtitle compound (4.39 g) was prepared according to the procedure in example 5 part b using 2-(2-phenyl-1-propoxy)acetic acid (5.0 g), oxalyl chloride 4.5 ml), concentrated ammonium hydroxide (20 ml), and toluene (30 ml).

Sources & evidence

ORD record
ord-26598ceca9594da1b1dcd681f8274b3b
Source dataset
uspto-grants-1999_12
Patent number
US06008365

Linked notes

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