Phenol → (2-Chloro-1-methoxyethoxy)benzene
Reaction equation
[CH3:1][O:2][CH:3]=[CH2:4].[C:5]1([OH:11])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[Cl:12]OC(C)(C)C>O1CCCC1>[CH3:1][O:2][CH:3]([O:11][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:4][Cl:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
At -20° C., 10 parts by weight of vinyl methyl ether is added all at once to 4.5 parts by weight of phenol in 50 parts by weight of tetrahydrofuran. Over a period of 30 minutes and at -20° C., 10 parts of tert.-butyl hypochlorite (Org. Synthesis, Coll. Vol. IV, 125, John Wiley & Sons, Inc., New York/London, 1963) is dripped into this mixture. The resultant mixture is allowed to come to room temperature. After stirring for 2 hours at room temperature, the solvent is removed, and distillation gives 5 parts by weight of 1-methoxy-1-phenoxy-2-chloroethane, b.p. 89°-91° C./4mm Hg.