Ethyl Acetate → 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)butan-1,3-dione

HRID 617790

Reaction equation

HRID 617790 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11](=[O:13])[CH3:12])[C:5]=2[O:4][CH2:3][CH2:2]1.[H-].[Na+].[C:16](OCC)(=[O:18])[CH3:17]>>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11](=[O:13])[CH2:12][C:16](=[O:18])[CH3:17])[C:5]=2[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 8857Ethyl AcetateHCID 24758Sodium hydrideHCID 212680521-(2,3-Dihydro-1,4-benzodioxin-5-yl)ethanone

Product 1

HCID 218462911-(2,3-Dihydro-1,4-benzodioxin-5-yl)butan-1,3-dione

Conditions

Temperature
80 °C

Procedure

1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-ethanone (1.2 g) was dissolved in 20 mL of ethyl acetate, and sodium hydride (0.33 g, 60% oil dispersion) was added. The reaction mixture was heated to 80° C. overnight, quenched with water, and neutralized with carbon dioxide to give an oily product of 1-(2,3-dihydro-1,4-benzodioxin-5-yl)butan-1,3-dione (0.37 g).

Workup

  1. customquenched with water

Sources & evidence

ORD record
ord-1cb07f9ef39e4699b1ed42ce0cba3e34
Source dataset
uspto-grants-1999_09
Patent number
US05952331

Linked notes

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