Trifluoroacetic acid → 4-(2-Propenyl)-1-methyl-5-pyrazole sulfonamide

HRID 620671

Reaction equation

HRID 620671 reaction equation
O[CH:2]([C:5]1[C:6]([S:15]([NH2:18])(=[O:17])=[O:16])=[N:7][N:8](C)[C:9]=1C(C)(C)C)[CH2:3][CH3:4].F[C:20](F)(F)C(O)=O>>[CH2:2]([C:5]1[CH:9]=[N:8][N:7]([CH3:20])[C:6]=1[S:15]([NH2:18])(=[O:17])=[O:16])[CH:3]=[CH2:4]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 212437394-(1-Hydroxypropyl)-1-methyl-5-tert-butylpyrazolesulfonamide

Product 1

HCID 212437414-(2-Propenyl)-1-methyl-5-pyrazole sulfonamide

Procedure

The alcohol (3.0 g) from Example 3 was stirred in 25 ml of trifluoroacetic acid at 68° C. for 30 minutes. The solution was allowed to cool to room temperature, and the volatile components were removed in vacuo to afford 510 mg of the desired sulfonamide, m.p. 157°-161° C.

Workup

  1. customthe volatile components were removed in vacuo

Sources & evidence

ORD record
ord-87a32f0f385641ae8075ac023a4c575f
Source dataset
uspto-grants-1989_04
Patent number
US04822403

Linked notes

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