Trifluoroacetic acid → 4-(2-Propenyl)-1-methyl-5-pyrazole sulfonamide
Reaction equation
O[CH:2]([C:5]1[C:6]([S:15]([NH2:18])(=[O:17])=[O:16])=[N:7][N:8](C)[C:9]=1C(C)(C)C)[CH2:3][CH3:4].F[C:20](F)(F)C(O)=O>>[CH2:2]([C:5]1[CH:9]=[N:8][N:7]([CH3:20])[C:6]=1[S:15]([NH2:18])(=[O:17])=[O:16])[CH:3]=[CH2:4]Participants
3
Procedure
The alcohol (3.0 g) from Example 3 was stirred in 25 ml of trifluoroacetic acid at 68° C. for 30 minutes. The solution was allowed to cool to room temperature, and the volatile components were removed in vacuo to afford 510 mg of the desired sulfonamide, m.p. 157°-161° C.
Workup
- customthe volatile components were removed in vacuo
Sources & evidence
- ORD record
- ord-87a32f0f385641ae8075ac023a4c575f
- Source dataset
- uspto-grants-1989_04
- Patent number
- US04822403
Reaction notes
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