Triethylamine → HCID 21243981, compound

HRID 620680

Reaction equation

HRID 620680 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([OH:23])=[O:22])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1.[O:24]1[C:26]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:25]1.C(N(CC)CC)C>O1CCCC1.C(Cl)Cl>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([O:23][CH2:25][CH:26]([OH:24])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[O:22])=[CH:19][CH:20]=2)=[CH:11][CH:10]=1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 14299145Epoxy-styreneHCID 22242497HCID 22242497, compound

Product 1

HCID 21243981HCID 21243981, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 26.6 g of 4'-(6-hydroxyhexyloxy)(1,1')-biphenyl-4-carboxylic acid, 16 g of epoxystyrene and 16 g of triethylamine in 300 ml of tetrahydrofuran is heated at the boiling point for 140 hours. It is diluted with 1000 ml of methylene chloride, washed twice with 2N hydrochloric acid and dried over sodium sulfate. After concentration under reduced pressure, the residue is crystallized from ethanol. 2-Hydroxy-2-phenylethyl 4'-(6-hydroxyhexyloxy)-(1,1')-biphenyl-4-carboxylate is obtained; melting point: 148°-150°.

Workup

  1. washwashed twice with 2N hydrochloric acid
  2. dry with materialdried over sodium sulfate
  3. concentrationAfter concentration under reduced pressure
  4. customthe residue is crystallized from ethanol

Sources & evidence

ORD record
ord-eed9bfa7fce04b72ba6f37a25675ea79
Source dataset
uspto-grants-1989_04
Patent number
US04822682

Linked notes

Loading…