Reaction equation
[N+:1]([CH:4]=[C:5]1[NH:9][CH2:8][CH2:7][NH:6]1)([O-:3])=[O:2].[H-].[Na+].[H][H].[CH3:14][O:15][C:16]1[C:17]([N+:24]([O-:26])=[O:25])=[N:18][C:19]([CH2:22]Br)=[CH:20][CH:21]=1.[CH3:27]N(C)C=O>>[CH3:14][O:15][C:16]1[C:17]([N+:24]([O-:26])=[O:25])=[N:18][C:19]([CH3:22])=[CH:20][C:21]=1[CH2:27][N:6]1[CH2:7][CH2:8][NH:9][C:5]1=[CH:4][N+:1]([O-:3])=[O:2]Participants
Conditions
- Temperature
- 60 °C
Procedure
Nitromethyleneimidazolidine (1.3 g) was dissolved in dry dimethylformamide (15 ml), and sodium hydride (0.26 g) was added. The mixture was stirred at room temperature until the generation of hydrogen ceased. Subsequently, a solution of 2.4 g of 3-methoxy-2-nitro-6-pyridylmethyl bromide in 5 ml of dimethylformamide was added, and the mixture was stirred at 60° C. for 15 minutes. The reaction mixture was cooled to room temperature, poured into 50 ml of ice water, and extracted with dichloromethane. Dichloromethane was distilled off under reduced pressure, and ethanol was added to the residue to precipitate crystals. The crystals were collected by filtration and washed with ethanol to give 1-(3-methoxy-2-nitro-6-methylpyridylmethyl)-2-nitromethyleneimidazolidine (0.4 g). mp. 177°-181° C.
Workup
- temperatureThe reaction mixture was cooled to room temperature
- extractionextracted with dichloromethane
- distillationDichloromethane was distilled off under reduced pressure, and ethanol
- additionwas added to the residue
- customto precipitate crystals
- filtrationThe crystals were collected by filtration
- washwashed with ethanol
Sources & evidence
- ORD record
- ord-4cdc866464844c1c9043c9b082818713
- Source dataset
- uspto-grants-1988_09
- Patent number
- US04772620
Linked notes
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