2-Aminopyridine-4-carboxylic acid → HCID 67509665, compound

HRID 623658

Reaction equation

HRID 623658 reaction equation
Cl.[F:2][C:3]([F:15])([F:14])[CH2:4][O:5][C:6]1[N:11]=[CH:10][C:9]([CH2:12][NH2:13])=[CH:8][CH:7]=1.[NH2:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][N:25]=1)[C:20](O)=[O:21]>>[NH2:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][N:25]=1)[C:20]([NH:13][CH2:12][C:9]1[CH:10]=[N:11][C:6]([O:5][CH2:4][C:3]([F:2])([F:14])[F:15])=[CH:7][CH:8]=1)=[O:21]

Participants

3

Reactant 2

HCID 2783962-Aminopyridine-4-carboxylic acidHCID 67508831HCID 67508831, compound

Product 1

HCID 67509665HCID 67509665, compoundYield 29%

Procedure

The title compound is prepared in 29% yield (182 mg, a white solid) from (6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride (473 mg, 1.95 mmol) and 2-aminoisonicotinic acid (269 mg, 1.95 mmol) by the similar manner in Step-1 of Example-8.

Sources & evidence

ORD record
ord-729e19a3c2fd49c181aa3f8739096675
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Linked notes

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