Hydrochloric Acid → 2-(1,2,4-Oxadiazol-3-yl)propan-2-amine hydrochloride
Reaction equation
[O:1]1[CH:5]=[N:4][C:3]([C:6]([NH:9]C(=O)OC(C)(C)C)([CH3:8])[CH3:7])=[N:2]1.[ClH:17]>C(OCC)(=O)C>[ClH:17].[CH3:7][C:6]([NH2:9])([C:3]1[N:4]=[CH:5][O:1][N:2]=1)[CH3:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
tert-Butyl 2-(1,2,4-oxadiazol-3-yl)propan-2-ylcarbamate (0.668 g, 2.9 mmol) was dissolved in in ethyl acetate saturated with hydrochloride (10 mL) and stirred at room temperature for 0.5 h. Then it was concentrated to give product (0.45 g, 94%); MS (EI): m/e=128.2 [M+H]+.
Workup
- concentrationThen it was concentrated
Sources & evidence
- ORD record
- ord-60aba888a71a439d9c8060bbefb7bf3b
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09321727B2
Reaction notes
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