Hydrochloric Acid → [2-[(3-Amino-2-pyridinyl)[3-(dimethylamino)propyl]amino]phenyl]phenylmethanone

HRID 637451

Reaction equation

HRID 637451 reaction equation
[CH3:1][N:2]([CH3:27])[CH2:3][CH2:4][CH2:5][N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:9][C:8]2[CH:23]=[CH:24][CH:25]=[N:26][C:7]1=2.Cl.C([OH:32])(C)C>>[NH2:9][C:8]1[C:7]([N:6]([CH2:5][CH2:4][CH2:3][N:2]([CH3:27])[CH3:1])[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:32])=[N:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 54961Tampramine

Product 1

HCID 53769600[2-[(3-Amino-2-pyridinyl)[3-(dimethylamino)propyl]amino]phenyl]phenylmethanone

Procedure

A solution of N,N-dimethyl-6-phenyl-11H-pyrido[2,3-b][1,4]benzodiazepine-11-propanamine in isopropyl alcohol is treated with 25% hydrochloric acid at 0° C. to give a solution of the title compound.

Sources & evidence

ORD record
ord-d064e09a3282460fb273e28eea8896c7
Source dataset
uspto-grants-1985_12
Patent number
US04556667

Linked notes

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