C([O-])=O.[NH4+].C([O:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17](=[O:23])[NH:18][CH:19]=[N:20]2)=[C:15]([O:24][CH:25]([CH3:27])[CH3:26])[CH:14]=1)C1C=CC=CC=1>[Pd].CN(C)C=O>[OH:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17](=[O:23])[NH:18][CH:19]=[N:20]2)=[C:15]([O:24][CH:25]([CH3:27])[CH3:26])[CH:14]=1Ammonium formate (9.5 g, 150 mmol) and 10% palladium on carbon (500 mg) were added to a solution of 7-(benzyloxy)-5-isopropoxyquinazolin-4(3H)-one (4.6 g, 15.0 mmol) in dimethylformamide (40 ml) and the mixture stirred at ambient temperature for 4 hours. The mixture was filtered through Celite and then evaporated under reduced pressure. The residue was stirred in water (100 ml) for 30 minutes and then filtered and washed with water (25 ml) and then dried to leave 7-hydroxy-5-isopropoxyquinazolin-4(3H)-one (3.3 g, 100% yield) as a white solid:
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