Ethyl Bromide → 2-Propoxybenzonitrile
Reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[C:10](=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[CH3:17]>CC(C)=O>[CH2:10]([O:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH2:16][CH3:17]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
75 g (630 ml) of 2-hydroxybenzonitrile are refluxed with 174 g (1.26 mol) of potassium carbonate and 232.2 g (1.89 mol) of ethyl bromide in 11 of acetone overnight. The solid is filtered off, the solvent is removed under reduced pressure and the residue is distilled under reduced pressure.
Workup
- filtrationThe solid is filtered off
- customthe solvent is removed under reduced pressure
- distillationthe residue is distilled under reduced pressure
Sources & evidence
- ORD record
- ord-14391829d174467b94563f979d0cda3d
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07696206B2
Reaction notes
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