Hydrochloric Acid → HCID 85875172, compound
Reaction equation
C(=O)([O-])O.[K+].Cl[CH2:7][C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[O:9].[C-:19]#[N:20].[K+].Cl>O>[C:19]([CH2:7][C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[O:9])#[N:20]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
2.8 g (20 mmol) potassium hydrogen carbonate were added to 8.3 g (40 mmol) 6-(chloracetamido) hexanoic acid dissolved in 25 ml water. 3.2 g (48 mmol) potassium cyanide was then added to the clear solution which was cooled on ice. The reaction mixture was stirred for 17 hours and was then acidified with HCl (2N). The residue after extraction was purified by chromatography (silica gel, solvent: ethyl acetate).
Workup
- temperaturewas cooled on ice
- extractionThe residue after extraction
- customwas purified by chromatography (silica gel, solvent: ethyl acetate)
Sources & evidence
- ORD record
- ord-89a04f08e9d6410690e8f9eb18855139
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07700306B2
Reaction notes
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