Hydrochloric Acid → HCID 59253266, compound

To a solution of methyl 2-{[1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-1H-benzimidazol-5-yl]sulfonyl}-2-methylpropanoate (Step G, 1.07 g, 2.64 mmol) in methanol (5 mL) and tetrahydrofuran (5 mL) was added 2N sodium hydroxide aqueous solution (5 mL) at room temperature. The mixture was stirred at room temperature for 3 h. The mixture was made acidic with 2N hydrochloric acid (pH ˜4) and concentrated under reduced pressure. The residue was dissolved in water (50 mL) and dichloromethane (50 mL). The aqueous layer was separated and extracted with dichloromethane (50 mL×2). The combined organic layers were dried over magnesium sulfate and concentrated under reduced pressure to afford the title compound (920 mg, 89%) as a white solid.

1. concentrationconcentrated under reduced pressure
2. dissolutionThe residue was dissolved in water (50 mL)
3. customThe aqueous layer was separated
4. extractionextracted with dichloromethane (50 mL×2)
5. dry with materialThe combined organic layers were dried over magnesium sulfate
6. concentrationconcentrated under reduced pressure

ORD record

ord-865b343fb78842be8fdd81404c4c7127

Source dataset

uspto-grants-2010_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07700618B2