Bis(2-chloroethyl) ether → 1,5-Bis(4-iodophenoxy)-3-oxapentane
Reaction equation
[OH-:1].[Na+].[I:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.Cl[CH2:12][CH2:13][O:14][CH2:15][CH2:16]Cl>C(O)CCC>[I:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:1][C:7]2[CH:8]=[CH:9][C:4]([I:3])=[CH:5][CH:6]=2)=[CH:6][CH:5]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture prepared by adding 3.08 g of sodium hydroxide and 40 ml of n-butanol to 15.4 g of 4-iodophenol was refluxed. 2 ml of n-butanol solution of 5.01 g of 1,5-dichloro-3-oxapentane was added dropwise to the above prepared mixture over a period of 5 minutes.
Workup
- customA mixture prepared
- temperaturewas refluxed
Sources & evidence
- ORD record
- ord-de601d7504a04544afaf93084d42b5be
- Source dataset
- uspto-grants-1993_09
- Patent number
- US05248826
Reaction notes
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