Reaction equation
[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].Cl.[NH2:10][OH:11].S([O-])([O-])(=O)=O.[Na+].[Na+].Cl[C:20](Cl)(Cl)[CH:21]([OH:23])O>Cl.O>[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:21](=[O:23])[CH:20]=[N:10][OH:11]Participants
7
Conditions
- Temperature
- 25 °C
Procedure
A solution of 39.4 g of 2-fluoroaniline in 32.4 ml of concentrated hydrochloric acid and 215 ml of water and then a solution of 77.6 g of hydroxylamine hydrochloride in 355 ml of water were added to a mixture of 886 g of sodium sulfate hydrated with 10 moles of water, 64.55 g of chloral hydrate and 850 ml of water and the mixture was heated to reflux with stirring over 45 minutes and reflux was maintained for 5 minutes. The mixture was cooled to 25° C. and held there for 45 minutes. The product was washed with water and dried at room temperature and then at 70° C. under reduced pressure to obtain 56.8 g of N-(2-fluorophenyl)-2-hydroxyimino-acetamide melting at 120° C.
Workup
- temperaturethe mixture was heated
- temperatureto reflux
- temperaturereflux
- temperaturewas maintained for 5 minutes
- waitheld there for 45 minutes
- washThe product was washed with water
- customdried at room temperature
Sources & evidence
- ORD record
- ord-774177d7814b4100ad59869671066252
- Source dataset
- uspto-grants-1988_04
- Patent number
- US04736033
Linked notes
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